Specific and Precise Immune Response
CMDC Labs offers specific and precise immune response surface testing to identify the reactions of the body’s immune system cells and fluids to the presence of a substance or surface which is not recognized as a constituent of the body itself.
The Value of Immune Response Surface Testing
Understanding the foreign body response to a biomaterial is vital for predicting short- and long-term cell/tissue response. Medical device surfaces that contact tissues may initiate an inflammatory and wound-healing response that can be characterized by several different biological responses, including:
- Protein and platelet adsorption
- Adhesion and triggering of inflammatory cells, such as:
- T cells
- Natural killer cells
- And others
- Cytokine release and/or reactive oxygen and nitrogen release
Inflammatory and wound healing events that occur at a tissue/biomaterial interface upon implantation and the persistence of any type of inflammatory response could directly impact the biocompatibility and function of an implanted device. As such, direct evaluation of biomaterial interaction with blood components should be completed in conjunction with pursuing further cytocompatibility studies.
Characterization of a host’s inflammatory response to a bioactive or bioinert surface can be simulated using in vitro models. At CMDC Labs, we are equipped to fully characterize the human immune response to medical device surfaces in vitro by performing a variety of highly technical protein- and cell-based assays. Additionally, our scientists have developed proprietary competitive assays to quickly assess the immune response in relation to cytocompatibility.
Contact us today to learn more about immune response in vitro diagnostic testing, and making the unknown known with our prompt, innovative, and precise immune response surface testing.
Contact us today for expedited timelines, reduced costs and expert support from research to rollout.
You Will Start with the Right Testing to Accelerate the Whole Process
We do the right testing from the start to then generate the right data to provide an experience-based perspective on how to effectively use that data. Few organizations have been more innovative and integrative than ours in the realms of bioactive surface testing, antimicrobial surface testing and immune response testing.
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