• UNI EN ISO 10993-5-compliant cytotoxicity tests on cosmetics, chemicals, and medical devices.
• Cytotoxicity testing: performed in accordance with UNI EN ISO 10993-5 for medical devices.
• Testing for eye irritation using corneal epithelium from 3D-reconstructed monolayer cells.
• “Fluorescein leakage” eye corrosion tests (OECD 460).
• Skin irritation testing using in-vitro recreated epithelia of various origins and cell monolayers (OECD 439).
• Testing for skin corrosion: (OECD 431, 435).
• Testing for percutaneous absorption (OECD 428).
• Testing for skin sensitivity using dendritic cells and THP-1.
• Cell monolayers are used in the OECD 432 phototoxicity experiment.
• Mutagenesis in Ames tests (OECD 471).
• The in vitro assay for carcinogenesis (OECD guidance paper no. 231).
• Testing for ecotoxicity on seaweeds and Daphnia magna (OECD 202 and OECD 201).
• The ISO 10993-23 test for skin irritancy on 3D-reconstituted human epidermis.
• The ISO 10993-23 test for skin irritancy on 3D-reconstituted human epidermis.
• Testing for irritation on 3D-reconstituted human epithelia (respiratory, vaginal, gingival, etc.).
• Tests for eye irritation (OECD 491, 492, 492B, and 496).
• The OECD 442D (keratinosens) assay for skin sensitization.
• The OECD 442E (IL-8 Luc Assay, hCLAT, GARDTM) skin sensitization assay.
• IL-18 RHE Assay, SENS-IS, a skin sensitization test on 3D reconstituted human skin.
• The 3D epidermis phototoxicity assay (OECD 498).
• The OECD 301F Biodegradability Test.
• The Comet assay for mutagenesis in mammalian cells.
• Tests to assess the effects of hormone and endocrine disruptors (OECD 456, 458, 455).
• Tests on human reconstituted 3D epidermis and epithelia, ex vivo epidermis, damaged epidermis, etc. using Franz cells for percutaneous absorption.
• Cytotoxicity experiments to calculate the oral LD50 value in vitro (OECD reference document 129).
• CMDC Labs provides in-vitro efficacy testing for:
• Testing skin cells for antioxidant and antiradical activity (ROS analysis);
• The es ORAC Test, a direct antioxidant activity assessment.

Testing for mitogenic activity, protein synthesis stimulation, and extracellular matrix (collagen, elastin, fibronectin, etc.) stimulation of protein synthesis are all used to assess the anti-ageing and redensifying activities of the skin.

• Evaluation of the anti-inflammatory effects on skin cells and in-vitro recreated epithelia of various origins;
• Analyzing the pro-inflammatory potential of cytokines and growth factors (GM-CSF, TNF-, IL-1, IL-1, IL-8);
• Testing for cell proliferation using skin cells;
• Melanogenesis modulation testing, which involves boosting or suppressing the production of melanin for depigmentation or pigmentation products;
• Skin barrier testing on recreated skin; • Percutaneous absorption testing on skin constructed using the OECD 428 approach;
• Testing the keratolytic effect on skin that has been rebuilt;
• Endothelial cell and fibroblast wound healing activity testing (healing agents, stretch mark preventatives).
• Immune response modulation testing, which involves examining specific mediators (such as histamine, IL-1, and TNF) for their anti-itch, sensitization-inhibiting, and immunostimulant properties;